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KMID : 1140820170120020077
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Urogenital Tract Infection
2017 Volume.12 No. 2 p.77 ~ p.81
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The Antibiotic Susceptibility of Escherichia coli from Community-Acquired Uncomplicated Urinary Tract Infection: A Focused on Fosfomycin
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Choe Hyun-Sop
Lee Seung-Ju
Chang In-Ho
Kim Tae-Hyoung
Chung Hong
Chung Jae-Min
Lee Sang-Don
Jung Jae-Hung
Kim Ki-Ho
Min Seung-Ki
Na Yong-Gil
Yoon Ha-Na
Yu Ho-Song
Lee Mi-Kyung
Lee Sun-Ju
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Abstract
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Purpose: To assess the antibiotic susceptibility of Escherichia coli from community-acquired uncomplicated urinary tract infection (UTI).
Materials and Methods: Between August and December of 2015, confirmed cases of E. coli as a pathogen of community-acquired uncomplicated UTI were collected and assessed for antibiotic susceptibility in 10 designated hospitals. Additional fosfomycin susceptibility test was performed by a central laboratory using the disk diffusion method.
Results: A total of 347 E. coli isolates were collected from urine samples of community-acquired uncomplicated UTIs patients. The susceptibility rates of antibiotics were as follows: amikacin 100.0% (347), imipenem 100.0% (347), ciprofloxacin 57.1% (198), cefotaxime 74.9% (260), ampicillin 30.0% (104), trimethoprim/sulfamethoxazole 66.9% (232), and fosfomycin 98.0% (340). All fosfomycin-resistant E. coli isolates were extended-spectrum β-lactamase (ESBL)-producing. In 85 cases of ESBL-producing E. coli, the fosfomycin susceptibility rate was 91.8% (78/85).
Conclusions: Fosfomycin may be a useful option for the treatment of community-acquired uncomplicated UTIs. Further studies evaluating the role of fosfomycin in the treatment of UTIs and its clinical efficacy are necessary.
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KEYWORD
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Drug resistance, Fosfomycin, Urinary tract infections
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